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P-CRESYL 3-OXO-3-PHENYLPROPIONATE

CAS 67801-43-8
60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

P-Cresyl 3-Oxo-3-Phenylpropionate is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

p-Cresyl 3-oxo-3-phenylpropionate (also called p-tolyl 3-oxo-3-phenylpropionate) is an ester of p-cresol with phenylpyruvic acid. The compound is listed in the EU CosIng database and used as a fragrance ingredient in cosmetics. The cresol component introduces regulatory attention since p-cresol and its derivatives are subject to assessment under EU Regulation 1223/2009 for phenols and aromatic hydroxy compounds. RIFM and IFRA have assessed this ester and provided use level guidelines to manage any cresol-related toxicity concerns while allowing safe use in fragrance applications.

Skin benefits

  • Sweet, herbaceous-spicy fragrance with good substantivity
  • Used as a floralizer and fixative in perfume compositions

Known concerns

  • Cresol component subject to EU regulatory scrutiny for phenolics
  • Fragrance allergen declaration thresholds apply
  • IFRA guidelines control use levels in various product categories
  • Potential for hydrolysis releasing cresol in skin contact applications

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.