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P-PHENYLENEDIAMINE HCL

CAS 624-18-0
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A highly restricted hair dye intermediate with severe sensitization risks, permitted only in oxidative hair dye formulations under strict EU controls.

p-Phenylenediamine hydrochloride is the salt form of the primary hair dye intermediate PPD, classified under EU Annex III restriction III/8a. The SCCS has determined that PPD derivatives present high sensitization risk, and the EU cosmetics regulation requires specific labeling and handling precautions. This ingredient is prohibited for use in eyelash and eyebrow products (Regulation EU 2017/745) and is restricted to professional use oxidative hair dye formulations only in the EU market. Consumer self-application products face particular regulatory scrutiny.

Known concerns

  • Severe skin sensitization risk (H317)
  • EU Annex III restricted - III/8a (oxidative hair dye only)
  • Prohibited for eyelash/eyebrow products
  • Professional use restrictions apply in EU

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.