Skin Conditioning
PALMITOYL S-HIV-1 PENTAPEPTIDE-1
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A palmitoyl synthetic peptide with a sequence modeled on HIV-1 viral protein. Highly unusual cosmetic ingredient with minimal safety review — approach with caution.
This ingredient is a palmitoylated pentapeptide synthetic sequence derived from a fragment of the HIV-1 viral protein. The rationale in cosmetic marketing is that certain viral peptide sequences modulate host cellular pathways of interest for anti-aging (e.g., apoptosis or senescence signaling). As a pharmacological concept this is speculative; public safety and efficacy data are essentially absent outside supplier documents. No CIR or SCCS review. Regulatory status is jurisdiction-dependent — most competent authorities are skeptical of ingredients marketed on viral-protein-mimetic claims. Typical use is at very low concentration (parts-per-million-level). Given the lack of peer-reviewed data, default-cautious scoring is appropriate.
Skin benefits
- Lipidated synthetic peptide — positioned for immunomodulatory/skin-defense claims
- Very low cosmetic use concentrations
Known concerns
- INCI name derives from HIV-1 viral protein sequence — pharmacological/immunological concern
- No CIR or SCCS review
- Regulatory status in cosmetics is ambiguous
- Safety data extremely limited
- Marketing claims around viral-protein-mimetic peptides are inherently dubious
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.