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PEG-3 2,2'-DI-P-PHENYLENEDIAMINE

CAS 144644-13-3
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A PEG-linked diphenylenediamine used as a secondary intermediate in oxidative hair dyes; explicitly restricted under EU Annex III (reference II/1234) due to carcinogenic potential.

This dimeric phenylenediamine derivative is connected via a polyethylene glycol-3 linker and functions as a secondary intermediate in oxidative hair dye systems, contributing to the final color development through oxidative coupling reactions. EU Annex III reference II/1234 specifically restricts this compound, indicating the SCCS identified concerns regarding its carcinogenic or genotoxic potential during hair dye use. The PEG linker modifies toxicokinetics but does not eliminate concerns related to the diphenylenediamine structure. Products containing this ingredient require careful labeling and are typically restricted to professional use only.

Known concerns

  • Explicit EU Annex III restriction (II/1234) indicating carcinogenic concern
  • Genotoxic and mutagenic potential identified by SCCS
  • Skin sensitization documented
  • Restricted to professional use in EU

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.