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PEG-45 BIS-(TOCOPHERYL SUCCINATE)
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A PEGylated vitamin E succinate polymer that provides antioxidant benefits with enhanced water solubility, though PEG components carry some regulatory attention.
PEG-45 Bis-(Tocopheryl Succinate) is a polyethylene glycol (PEG n=45) conjugate of vitamin E succinate, providing amphiphilic character with antioxidant functionality. The succinate ester preserves tocopherol's antioxidant activity while PEGylation enhances water dispersibility for cosmetic emulsions. EU Regulation 1223/2009 permits PEG derivatives of vitamin E for cosmetic use; the ingredient has no Annex restrictions. PEG-chain length and molecular weight (~4000 Da for PEG-45) limit dermal absorption, supporting safe topical use.
Skin benefits
- Antioxidant protection from vitamin E succinate moiety
- Enhanced water solubility vs. free tocopherol
- May support skin lipid replenishment
- Amphiphilic emulsifying properties
Known concerns
- PEG component – potential concern for compromised skin barrier
- Not recommended for very dry or barrier-impaired skin
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.