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penmesterol

CAS 67-81-2
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Penmesterol is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Penmesterol (17α-methylandrost-5-en-3β,17β-diol) is a steroidal anabolic agent with potent androgenic activity. The EU Cosmetics Regulation 1223/2009 Annex II explicitly bans substances with hormonal activity in cosmetic products. As an anabolic steroid with endocrine-disrupting properties, it is classified as a CMR Substance (Carc. 1B, Repr. 1A) and is prohibited in all cosmetic categories without exception.

Known concerns

  • EU Annex II banned — CMR substance (carcinogenic, mutagenic, toxic for reproduction)
  • Endocrine-disrupting anabolic steroid
  • No safe cosmetic use — pharmaceutical drug substance

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.