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phenylpropanolamine

CAS 14838-15-4
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Phenylpropanolamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Phenylpropanolamine (PPA) is a non-phenylephrine sympathomimetic amine that acts as a decongestant and norepinephrine releasing agent. It carries documented cardiovascular risks including hypertension, stroke risk, and arrhythmia potential. Regulatory agencies including the FDA have restricted its use in non-prescription products. For cosmetic topical application, its vasoconstrictive properties and absence from INCI-approved lists indicate it would be regulated similarly to other sympathomimetic amines under EU Annex III.

Known concerns

  • Cardiovascular risk (hypertension, stroke)
  • Vasoconstrictive activity
  • Not approved in EU cosmetics ingredient lists
  • Sympathomimetic amine with drug activity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.