Botanical active
PIPERLONGUMININE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Pyrrolidine alkaloid amide from long pepper (Piper longum), studied for antioxidant and anti-inflammatory activity. Limited cosmetic safety review and structural relation to bioactive alkaloids warrant cautious use.
Skin benefits
- Plant alkaloid from Piper longum with reported antioxidant effects
- Anti-inflammatory potential in vitro
- Investigated for melanogenesis modulation
- Traditional use in herbal preparations
Known concerns
- Closely related to piperlongumine, a compound with documented genotoxicity in research models
- No CIR or SCCS cosmetic safety opinion located
- Bioactive alkaloid with potential off-target effects
- Limited dermal safety data
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related botanical actives
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.