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Poldine metilsulfate (INN)

CAS 545-80-2
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Poldine Metilsulfate (inn) is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Poldine metilsulfate is a synthetic anticholinergic agent (quaternary ammonium salt) developed as an antispasmodic and anti-ulcer drug. It has no established use or benefit in cosmetic formulations and carries pharmacological activity (systemic anticholinergic effects) that makes it inappropriate for skin care applications. No EU cosmetic Annex listing exists, and it is not a recognised cosmetic ingredient. Its safety for cosmetic use has not been established.

Known concerns

  • Pharmacological/anticholinergic activity — not appropriate for cosmetic use
  • No established safety profile for topical cosmetic application
  • Quaternary ammonium structure — potential for skin penetration concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.