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PROLYL HISTAMINE HCL

CAS 179308-53-3
62

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Prolyl Histamine Hcl is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Prolyl histamine HCl is a synthetic dipeptide amide combining proline (an amino acid) with histamine (an imidazole amine involved in inflammatory signaling). The ingredient functions as a skin-conditioning active with purported anti-inflammatory and barrier-supporting properties. Under EU cosmetic regulation it is not specifically restricted but requires full safety assessment. The histamine moiety warrants consideration for potential sensitization reactions in histamine-sensitive individuals, though peptide conjugation significantly modifies histamine's pharmacological activity.

Skin benefits

  • Modulates local inflammatory signaling pathways
  • Supports skin homeostasis and barrier resilience
  • May reduce redness and discomfort in sensitive skin

Known concerns

  • Histamine component — theoretical irritation/sensitivity concern for reactive individuals
  • Limited long-term clinical data for this specific derivative
  • Must be fully safety-assessed under Regulation (EC) No 1223/2009

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.