S-COW DECAPEPTIDE-4 AMIDE

About S-COW DECAPEPTIDE-4 AMIDE

A synthetic decapeptide based on a bovine milk protein, modified with an amide at the C-terminus and used for antimicrobial and anti-sebum benefits.

Detailed Analysis

This 10-amino-acid synthetic peptide is modelled on a sequence from RiLK1, a protein found in Bos taurus (cow) milk, with an amide group at the C-terminus to improve stability. The small size and purely synthetic production eliminate risks of animal-derived contamination or microbial toxins. EU cosmetic regulation has no specific restrictions on synthetic bovine-derived peptides, and the ingredient is governed by general peptide provisions (Annex II entry 416). The C-terminal amide modification is common in cosmetic peptides and generally improves stability without altering safety profile.

What It Does

Skin Benefits

• ✓ Antimicrobial properties may help control acne-causing bacteria
• ✓ Anti-sebum activity may reduce excess oiliness
• ✓ Stable amide terminus may provide extended efficacy on skin

Known Concerns

• ⚠ Bovine origin — risk of transmitting animal pathogens if not purely synthetic
• ⚠ Antimicrobial function may disrupt normal skin microbiome balance with prolonged use
• ⚠ Small size allows potential penetration of skin barriers

References