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Skin Conditioning

SH-DNA-1

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic short-hairpin DNA fragment coding for human microRNA mir-434-5p — marketed for gene-expression modulation. No SCCS opinion, limited topical safety data and unclear long-term effects warrant caution.

Skin benefits

  • Theoretical gene-expression modulation
  • Novel biotechnology approach

Known concerns

  • No SCCS opinion to date
  • microRNA mimic mechanism lacks long-term topical safety data
  • Stability and skin penetration poorly characterized
  • Sparse public toxicology

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.