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Antioxidant

SH-POLYPEPTIDE-66

82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A biosynthetic copy of human Sirtuin 1, a cellular stress-response protein, used as an antioxidant skin conditioner. Modern recombinant ingredient with no documented cosmetic concerns at use levels.

Function

ANTIOXIDANTHAIR CONDITIONINGSKIN CONDITIONING

Skin benefits

  • Biosynthetic Sirtuin 1 analog as antioxidant conditioning agent
  • Supports cellular stress-response signaling
  • High-purity E. coli production

Known concerns

  • Limited public cosmetic safety data
  • Topical penetration of large enzyme limited
  • Possible immunogenicity from residual host proteins

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.