Conditioning Agent
SILKWORM RH-OLIGOPEPTIDE-2
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant Insulin-Like Growth Factor 1 produced in transgenic silkworms, subject to EU restriction II/416, indicating regulatory safety concerns from the SCCS.
Silkworm rh-Oligopeptide-2 is a recombinant human IGF-1 (up to 195 amino acids) produced in transgenic silkworm (Bombyx mori). The restriction code 'II/416' indicates this ingredient has undergone SCCS review and carries specific safety restrictions under EU cosmetic Regulation 1223/2009. IGF-1 is a potent growth factor with significant mitogenic activity, and the EU restriction reflects identified concerns about cosmetic use of this growth factor peptide.
Function
Skin benefits
- Skin conditioning
Known concerns
- EU restriction II/416 applies - specific conditions required
- IGF-1 is a potent mitogenic growth factor
- SCCS review indicates safety concerns
- Requires compliance with specific use conditions
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.