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SOPHORA FLAVESCENS ROOT EXTRACELLULAR VESICLES

68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Nanocarrier vesicles from Sophora flavescens root cultures delivering prenylated flavonoids with potent but potentially sensitising anti-inflammatory effects.

Sophora Flavescens Root Extracellular Vesicles are secreted by cultured adventitious roots into the growth medium. The vesicles carry kushenols (prenylated flavonoids), kurarinone, matrine, and oxymatrine alkaloids as the active payload. Kushenols are potent NADPH oxidase and xanthine oxidase inhibitors providing strong anti-inflammatory effects. However, prenylated flavonoids are known contact sensitisers, and the alkaloid content adds concern. Topical use should avoid high concentrations.

Skin benefits

  • Strong anti-inflammatory
  • Antioxidant
  • Antimicrobial

Known concerns

  • Known contact sensitiser — prenylated flavonoids can cause allergic contact dermatitis
  • Alkaloid content warrants caution
  • EU Annex III potential restricted compound

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.