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TETRAPEPTIDE-105 BIS-CYCLOHEXYLPROPYL HISTIDINAMIDE

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A larger histidine-rich peptide analogue of the tripeptide variant, used for similar anti-aging and conditioning benefits.

Tetrapeptide-105 bis-cyclohexylpropyl histidinamide is a four-amino-acid peptide with the same cyclohexylpropyl histidinamide capping as the tripeptide analogue (tripeptide-107). The additional amino acid in the peptide chain may slightly modify the activity and receptor interaction profile. Both cyclohexyl groups and histidinamide residues are well-tolerated structural elements in topical formulations. The tetrapeptide version offers a different potency and binding profile compared to the tripeptide, allowing formulation flexibility. Not restricted under EU cosmetics law.

Skin benefits

  • Skin conditioning
  • Anti-aging
  • Barrier support from histidine-based NMF components

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.