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Skin Conditioning

TETRAPEPTIDE-121

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A four-amino-acid synthetic peptide used as a targeted skin-conditioning signal. Low use levels limit irritation, but independent data is thin.

Tetrapeptide-121 is a synthetic four-amino-acid peptide marketed for skin-conditioning and active signalling effects. Like most numbered cosmetic peptides it is used at parts-per-million concentrations, intrinsically limiting systemic exposure and irritation potential. There is no published SCCS or CIR opinion; toxicology rests on supplier dossiers. Short peptides as a class are generally non-sensitizing and rapidly metabolised on the skin. Specific efficacy claims should be viewed with caution until independent clinical evidence is available.

Function

SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Targeted skin-conditioning peptide
  • Used at parts-per-million levels
  • Low irritation potential

Known concerns

  • Limited public toxicology data
  • Efficacy claims supplier-driven
  • No SCCS or CIR opinion

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.