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Tretamine (INN)

CAS 51-18-3
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tretamine (INN) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Tretamine (INN, also known as triethylenemelamine or TEM) is a polyfunctional alkylating agent originally developed as a chemotherapy agent and later found in rodenticide applications. It is classified as a Category 1B carcinogen (H350) and Category 1B mutagen (H340) under the CLP regulation and appears on EU Annex II — the list of substances prohibited in cosmetic products. There is no safe cosmetic use case for this substance and it has no history of cosmetic formulation.

Known concerns

  • EU Annex II prohibited substance — banned in all cosmetic products
  • Confirmed Category 1B carcinogen (H350)
  • Confirmed Category 1B mutagen (H340)
  • Cytotoxic alkylating agent with no cosmetic rationale
  • Severe acute toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.