Other
TRIMETHYLAMINE OXIDE
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A naturally occurring trimethylamine N-oxide (TMAO) found in marine organisms, this compound is used as a humectant and skin conditioning agent in cosmetics and is considered safe with no EU restrictions at typical use concentrations.
Trimethylamine oxide (TMAO) is the N-oxide of trimethylamine, a naturally occurring compound found in many marine fish and invertebrates where it serves as an osmolyte and protein stabilizer. In cosmetics, it functions as a humectant and skin conditioning agent. EU CosIng lists this substance with no restrictions under Regulation (EC) No 1223/2009. The compound is not a sensitizer, not a significant eye irritant at use concentrations, and not prone to nitrosamine formation. It is considered one of the safer cosmetic ingredients with a long history of use in skin and hair care formulations.
Skin benefits
- Effective humectant — attracts and retains moisture in skin
- Skin conditioning agent improves skin smoothness
- Natural occurrence in marine organisms suggests biocompatibility
Known concerns
- May have a fishy odor at higher concentrations — fragrance considerations needed
- Generally regarded as safe but not extensively studied for ultra-high concentration use
- Trimethylamine (TMA) precursor — controlled formulation pH recommended
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.