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1-(4’-Aminophenylazo)-2-methyl- 4-(bis-2-hydroxyethyl) aminobenzene

CAS 104226-21-3
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An azo dye intermediate used in oxidative hair colouring, this compound is classified as acutely toxic (H301/H302) and a marine pollutant, and must be restricted to oxidative hair dye use only with strict concentration controls.

This aminophenylazo derivative is a primary intermediate used in the formation of oxidative hair dyes (azo coupling reactions). It carries the EU GHS hazard classification H301/H302 (toxic if swallowed / harmful if swallowed) and H335 (may cause respiratory irritation), along with H400/H410 (very toxic to aquatic life / toxic to aquatic life with long-lasting effects), necessitating the Danger signal word. In the EU, azo dye intermediates with acute oral toxicity are strictly controlled and must only be used at the point of mixing in oxidative hair dye preparations. This substance requires particular caution regarding accidental ingestion risk.

Known concerns

  • H301/H302: Acute oral toxicity
  • H335: Respiratory irritant
  • H400/H410: Very toxic to aquatic environment
  • Danger signal word — restricted to professional oxidative hair dye use
  • CMR (Carcinogenic/Mutagenic) potential of aromatic amines requires monitoring

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.