Other
1-Butyl-3-(N-crotonoylsulphanilyl)urea
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A sulfonylurea-type compound with potential pharmacological activity that has no established safety profile for topical cosmetic application.
A sulfonylurea derivative combining a butyl-substituted urea with a crotonoyl sulfanilyl moiety, structurally suggestive of hypoglycaemic pharmaceutical activity given the sulfonylurea pharmacophore. No EU cosmetic Annex listing exists, no GHS hazard statements are available, and no INCI safety assessment covers this ingredient for topical use. The total absence of safety data and structural alerts for pharmacological activity (sulfonylureas are oral hypoglycaemics) preclude any cosmetic application.
Known concerns
- Sulfonylurea pharmacophore – structural alert for hypoglycaemic activity
- No established safety profile for cosmetic use
- Unknown sensitisation and toxicological profile
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.