Other
2-CYANOMETHOXY-P-PHENYLENEDIAMINE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
2-Cyanomethoxy-P-Phenylenediamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
This hair dye intermediate combines the p-phenylenediamine scaffold with a cyanomethoxy substituent, creating a nitrile-functionalized aromatic amine suitable for oxidative coupling reactions in hair dye formulations. The nitrile (cyano) group introduces additional electronic effects on the aromatic system. Like other PPD derivatives, it is subject to EU Cosmetics Regulation Annex III restrictions with specific maximum concentrations and labelling requirements. The combination of aromatic amine sensitization risk and nitrile electronic effects requires careful safety evaluation in finished cosmetic products.
Known concerns
- Skin sensitizer - aromatic amine class
- EU Annex III restricted with concentration limits
- Nitrile functional group may contribute to toxicity profile
- Mandatory sensitization labelling
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.