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5-Amino-4-chloro-2-methylphenol hydrochloride

CAS 110102-85-7
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

5-amino-4-chloro-2-methylphenol Hydrochloride is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

5-Amino-4-chloro-2-methylphenol hydrochloride is a salt of a chlorinated aminophenol derivative used as an intermediate in permanent hair dye formulations. The compound contains both an amino group (providing dye precursor functionality) and a chlorine substituent. While not explicitly listed in EU Annex II as a prohibited substance, its structural similarity to other restricted aromatic amines raises regulatory scrutiny. The hydrochloride salt form can dissociate, releasing chloride ions that may affect skin barrier integrity in compromised skin. EU cosmetics regulation requires hair dye substances to undergo safety assessment, and this compound requires professional handling with appropriate protective measures during manufacturing.

Known concerns

  • Potential skin sensitization
  • Chloride ion release
  • EU regulatory scrutiny as hair dye intermediate
  • Requires professional handling

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.