Other
2-ETHYL-3,(5 OR 6)-DIMETHYLPYRAZINE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
2-ethyl-3,(5 or 6)-dimethylpyrazine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
2-Ethyl-3,(5 or 6)-dimethylpyrazine is a pyrazine derivative occurring naturally in cocoa, coffee, and grilled foods; used as a flavor and fragrance ingredient. Pyrazines in cosmetic use are typically limited to leave-on concentrations below 0.01% due to potential for skin and respiratory irritation. The ingredient is listed on FDA and EU flavor substance lists (FEMA GRAS) for food use; however, cosmetic topical application has less regulatory precedent. SCCS guidance notes insufficient data for pyrazine cosmetic safety but no immediate concern at trace levels.
Known concerns
- Limited cosmetic safety data - primarily food use
- May cause skin/eye irritation at higher concentrations
- Pyrazines can be respiratory irritants in aerosol products
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.