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3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one

CAS 127-51-5
68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic aromatic compound widely used as a fragrance ingredient in perfumes and cosmetics, giving a warm, floral-violet scent, but it is a known skin sensitizer.

Also known as Iso Gamma Super (or alpha-isomethyl ionone), this is a key fragrance chemical found in many commercial perfumes. It is one of the 26 fragrance allergens that must be declared on EU ingredient lists under Regulation (EC) 1223/2009 Annex III when present above 0.001% in leave-on or 0.01% in rinse-off products. It carries H317 (skin sensitisation), H411 (aquatic chronic toxicity), and H319 (eye irritation) hazard classifications.

Skin benefits

  • Provides pleasant aromatic scent to cosmetic formulations

Known concerns

  • EU-listed fragrance allergen requiring mandatory declaration
  • Skin sensitization potential (H317)
  • Aquatic toxicity concerns (H411, H412)
  • Eye irritation possible (H319)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.