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3-ETHYL-2,5-DIMETHYLPYRAZINE

CAS 13360-65-1
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

3-ethyl-2,5-dimethylpyrazine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

This symmetrical dimethyl-ethylpyrazine is a widely used food flavoring and fragrance material. It carries hazard statement H302 (harmfulful if swallowed) but lacks the multi-system irritation profile of its 3,5-dimethyl analog. IFRA restricts this pyrazine in cosmetic applications due to its sensitizing and irritant potential. The EU's SCCS has flagged pyrazines as a class requiring more data, contributing to a score in the 40-59 range for known sensitizers.

Known concerns

  • H302 — harmful if swallowed
  • IFRA-restricted pyrazine with concentration limits
  • SCCS flagged pyrazines as requiring further safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.