Skip to content

Banned Substance

4,4'-Bi-o-toluidine (ortho-Tolidine)

CAS 119-93-7
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

ortho-Tolidine is a benzidine-related aromatic amine, IARC Group 2A probable human carcinogen, banned in EU cosmetics. Linked to occupational bladder cancer.

Skin benefits

  • Used historically in clinical and industrial chemistry assays

Known concerns

  • EU Annex II banned in cosmetics
  • IARC Group 2A — probable human carcinogen
  • Bladder cancer risk in occupational exposure
  • Aromatic amine — strong skin sensitizer

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related banned substances

2
2,3-Epoxypropan-1-ol (Glycidol)
Banned Substance
 2
4,4'-Oxydianiline (p-aminophenyl ether) and its salts
Banned Substance
 2
Alkanes, C1-2, if they contain > 0.1% w/w Butadiene
Banned Substance
 2
Alkanes, C4-5, if they contain > 0.1% w/w Butadiene
Banned Substance
 2
Ammonium pentadecafluorooctanoate
Banned Substance
 2
Anthracene oil
Banned Substance
 2
Biphenyl-2-ylamine
Banned Substance
 2
Buta-1,3-diene, see also entries 464-611
Banned Substance

Check your shelf

Find 4,4'-Bi-o-toluidine (ortho-Tolidine) in your products.

Scan any cosmetic product with LuxSense to see if it contains 4,4'-Bi-o-toluidine (ortho-Tolidine) and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.