Skin Conditioning
ACETYL HEXAPEPTIDE-38
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic six-amino-acid peptide capped with an acetyl group for stability — used as a skin-conditioning active. Low-risk by class.
Acetyl Hexapeptide-38 is a defined-sequence synthetic hexapeptide whose N-terminus is capped with an acetyl group, a common modification that improves chemical stability and formulation compatibility versus the free peptide. Acetylated short peptides have a generally favorable safety profile in cosmetic use — low irritation, minimal sensitization, rapid breakdown to amino acids and acetate by skin enzymes. No specific CIR or SCCS opinion exists for this peptide. Independent peer-reviewed efficacy data is essentially absent; claims rely on supplier in vitro work.
Function
Skin benefits
- Skin conditioning
- Improved formulation stability
- Low irritation profile
Known concerns
- Limited independent data
- No regulatory dossier
- Supplier-driven claims
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.