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Skin Conditioning

ACETYL HEXAPEPTIDE-39

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic six-amino-acid peptide capped with an acetyl group for stability — used as a skin-conditioning active. Low-risk by class.

Acetyl Hexapeptide-39 is a defined-sequence synthetic hexapeptide with an N-terminal acetyl group, a common modification that improves chemical stability and formulation compatibility. Acetylated short peptides have a generally favorable safety profile in cosmetic use — low irritation, minimal sensitization, breakdown to amino acids and acetate by skin enzymes. No specific CIR or SCCS opinion exists. Independent peer-reviewed efficacy data is essentially absent; claims rely on supplier in vitro work.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Improved formulation stability
  • Low irritation profile

Known concerns

  • Limited independent data
  • No regulatory dossier
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.