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Skin Conditioning

ACETYL S-OCTOPUS PENTAPEPTIDE-1 SP

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic peptide inspired by an octopus-derived bioactive sequence, N-acetylated for stability. Novel cosmetic active; public data is thin.

This is a synthetic pentapeptide inspired by bioactive sequences identified in octopus (cephalopod) biology. Cephalopod peptides have drawn attention because of their potent biological activity (e.g., neuropeptide analogs). The N-acetyl group stabilizes the peptide against exopeptidases on skin and improves shelf life. In cosmetics it is marketed for firming/anti-aging and is used at very low concentrations typical of signal peptides (0.0001-0.01%). There is no CIR or SCCS review, and peer-reviewed cosmetic literature is limited to supplier materials. Safety at use levels is plausible based on class analogs but cannot be called "established".

Skin benefits

  • Synthetic peptide mimicking an octopus bioactive sequence
  • N-acetylation improves stability
  • Positioned as a signal peptide for skin firming
  • Low-concentration cosmetic use

Known concerns

  • Highly proprietary — minimal public safety/efficacy data
  • No CIR or SCCS review
  • Peptide-class potency requires appropriate use levels
  • Regulatory status depends on jurisdiction

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.