Skin Conditioning
ACETYL TETRAPEPTIDE-118
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An N-acetylated 4-amino-acid peptide for skin conditioning. The acetyl cap improves stability; safety profile is plausible but data is limited.
Acetyl Tetrapeptide-118 is a synthetic tetrapeptide bearing an acetyl group on its N-terminus, which improves stability and lipophilicity compared to the free peptide. It is supplied as a cosmetic active for skin-conditioning and signaling-type endpoints (firmness, visible aging) at parts-per-million levels in finished products. There is no CIR or SCCS opinion specific to this peptide and no published GHS hazard classification. As with other small synthetic peptides, intact systemic absorption is minimal and the principal risks are formulation-specific (preservative pairings, trifluoroacetate counterions, etc.). Independent efficacy literature is thin.
Function
Skin benefits
- Skin conditioning
- Stable acetylated peptide form
- Low irritation potential
Known concerns
- No regulatory monograph
- Sparse independent literature
- Efficacy data largely from supplier
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.