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Skin Conditioning

ACETYL TETRAPEPTIDE-27

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A 4-amino-acid peptide with an acetyl cap, used as a skin-conditioning active. Plausibly safe at trace levels; data is limited.

Acetyl Tetrapeptide-27 is a synthetic tetrapeptide modified at the N-terminus with an acetyl group, used in cosmetic formulations as a skin-conditioning agent at low ppm levels. The acetyl cap improves stability and lipophilicity. Numbered INCI peptides of this type are supplied by specialty ingredient houses for signaling-type benefits. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides have negligible intact skin penetration and very low irritation potential at use levels. Independent efficacy and long-term safety data are thin; risk in practice is dominated by the surrounding formulation.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Improved stability via acetylation
  • Low irritation potential

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.