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AMBREIN

CAS 473-03-0
67

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A natural tricyclic sesquiterpene alcohol from ambergris with fragrance and fixative properties, showing low acute toxicity but mild allergenic potential typical of natural fragrance materials.

Ambrein is the primary alcohol constituent of ambergris, the biliary secretion of the sperm whale (Physeter catodon). It is a tricyclic sesquiterpene with a characteristic warm, marine, sweet odor used as a high-quality fragrance fixative. Natural ambergris is now largely replaced by synthetic equivalents or verified sustainable sources due to CITES restrictions on endangered species. The EU Cosmetics Regulation does not ban ambrein itself, but requires verification of sustainable sourcing under CITES Appendix I/II. Toxicologically, it shows low acute toxicity with some structural similarity to known fragrance sensitisers, placing it in the mid-60s. IFRA standards apply and sensitisation testing in human subjects has not shown major concerns.

Skin benefits

  • Fragrance fixative — prolongs fragrance retention on skin
  • Provides characteristic warm, marine scent profile

Known concerns

  • Sourcing — must be verified sustainable/legally sourced under CITES (sperm whale product)
  • Natural product — batch variability and potential for contamination
  • Minor allergenic potential typical of sesquiterpene alcohol class
  • IFRA compliance documentation required for cosmetic use
  • No major EU restriction but national varietal restrictions may apply

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.