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BIS-COUMARAMIDOBUTANE

CAS -
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic coumarin derivative (N,N'-dicoumaroylputrescine) with moderate skin sensitization concerns; coumarin is a EU Annex III restricted fragrance allergen.

Bis-couaramidobutane is a dimeric coumarin derivative. Coumarin itself is listed on EU Regulation (EC) No 1223/2009 Annex III as a restricted fragrance allergen requiring declaration. PubChem score 58 reflects the known coumarin sensitization concerns, particularly for individuals with fragrance allergies.

Skin benefits

  • Antioxidant properties may protect against environmental damage
  • Conditioning agent for skin and hair

Known concerns

  • Skin sensitization potential (coumarin derivative)
  • EU Annex III restricted fragrance allergen
  • Patch testing recommended for sensitive individuals

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.