Cis-1-(3-chloroallyl)-3,5,7- triaza-1-azoniaadamantane chloride (cis-CTAC)
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.
Cis-1-(3-Chloroallyl)-3,5,7-Triaza-1-Azoniaadamantane Chloride (cis-CTAC) is a quaternary ammonium compound (QAC) structurally related to chlorhexidine and other antimicrobial preservatives. Quaternary ammonium compounds with 3-chloroallyl groups are associated with significant skin sensitization, and CTAC specifically has been prohibited in EU cosmetic products under Annex II (banned substances). The cis isomer designation indicates stereochemical purity concerns. Theadamantane cage structure and chloroallyl group contribute to its antimicrobial activity but also its toxicity profile.
Known concerns
- EU Annex II prohibited quaternary ammonium compound
- Known skin sensitizer
- Environmental toxicity concerns with quaternary ammonium compounds
- Potential for bacterial resistance development
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.