Fragrance
DECAHYDROCYCLODODECAOXAZOLE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A macrocyclic nitrogen-oxygen heterocycle used as a specialty fragrance fixative. Low public data — conservative yellow default.
Decahydrocyclododecaoxazole (CAS 38303-23-0) is a macrocyclic oxazoline-type fragrance material employed for its diffusive, musk-adjacent character and fixative properties. Public SCCS/CIR/RIFM documentation for this specific structure is limited, and much of the safety assessment is held privately by the fragrance industry under IFRA standards. Macrocyclic materials of this size generally exhibit low systemic toxicity due to poor bioavailability, but specific data for this compound is thin. Conservative yellow-tier assignment reflects the low-evidence environment rather than identified hazards.
Function
Skin benefits
- Fragrance longevity
- Musk-adjacent character
Known concerns
- Limited public safety data
- Default-down for obscure structures
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related fragrances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.