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CIS,CIS-1,1'-(ETHYLIDENEBIS-OXY)DIHEX-3-ENE

CAS 63449-64-9
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cis,cis-1,1'-(ethylidenebis-Oxy)dihex-3-Ene is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

This compound is a bis-acetal formed from two molecules of cis-3-hexenal bound via an ethylidene acetal linkage. Used primarily as a fragrance enhancer and fixative, it imparts green, vegetable-like notes. No entry exists in EU Annex II (banned) or Annex III (restricted substances), but the compound's acetal structure raises some concern for gradual hydrolysis in aqueous formulations, releasing the constituent aldehyde. GHS classification may apply depending on supplier data.

Skin benefits

  • Fragrance material with no documented direct skin benefits

Known concerns

  • Limited available toxicological and sensitization data
  • Environmental hazard (acetal structure)
  • Potential hydrolysis in water-based formulations releasing aldehydes

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.