Other
CUCURBITURILS
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A family of macrocyclic glycouril-based host molecules that can encapsulate fragrance molecules, active ingredients, and preservatives, potentially improving formulation stability and controlled release.
Cucurbiturils are cyclic oligomers of glycouril bridged by methylene groups, with cavity sizes that can host small to medium-sized organic molecules. They are among the newer excipients in cosmetic science, primarily used for fragrance stabilisation and controlled delivery of actives. Their macrocyclic structure renders them chemically inert and of low toxicity; oral and dermal studies in rodents have shown minimal adverse effects. They are not restricted under EU cosmetic regulations and are considered a promising encapsulation platform for cosmetic applications.
Skin benefits
- Fragrance stabilisation and controlled release reducing volatilisation
- Encapsulation of sensitive actives (e.g., vitamins) improving shelf-life
- Potential for reduced skin irritation from encapsulated fragrance allergens
Known concerns
- Limited long-term human safety data as cosmetic ingredient
- Encapsulation may alter bioavailability of co-formulated actives unexpectedly
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.