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diethylthiambutene

CAS 86-14-6
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Diethylthiambutene is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Diethylthiambutene is a structural analogue of dimethylthiambutene, sharing the same 3,3-diethyl-1-methyl-4-phenylpiperidine-4-like thiambutene backbone. It is a mu-opioid agonist with analgesic potency comparable to morphine. No safety dossier exists for cosmetic or topical use. Under EU Regulation (EC) No 1223/2009 Annex II (substances prohibited in cosmetic products), opioid pharmacophores without cosmetic benefit are explicitly prohibited.

Known concerns

  • Potent opioid agonist — severe opioid toxicity risk
  • Prohibited in EU cosmetics Annex II
  • No cosmetic safety data
  • High dependence liability

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.