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DIMETHOXYAPIGENIN

CAS 520-32-1
72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dimethoxyapigenin is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Dimethoxyapigenin (CAS 520-32-1) is a methylated flavone derivative of apigenin, found in certain plants. It functions as a UV absorber and demonstrates anti-inflammatory, antioxidant, and tyrosinase-inhibiting activity. While not specifically listed in EU CosIng Annex restrictions, its classification as a flavone with potential photosensitising concerns when used in sun-exposed formulations warrants attention. It is not currently a widely regulated cosmetic ingredient but lacks a full established safety dossier.

Skin benefits

  • UV-absorbing properties for photoprotection
  • Anti-inflammatory activity beneficial for skin calming
  • Antioxidant protection
  • Tyrosinase inhibition suggesting potential skin-lightening effects

Known concerns

  • Limited cosmetic-specific safety data
  • Potential photosensitisation concern in sun-exposed formulations
  • Not extensively reviewed under EU CosIng

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.