Skin Conditioning
DIPEPTIDE-28 NICOTINATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A short synthetic peptide esterified with nicotinic acid (niacin) — for skin conditioning. Generally well tolerated; mild flushing possible in sensitive users.
Dipeptide-28 Nicotinate is a synthetic two-amino-acid peptide chemically conjugated to nicotinic acid (niacin). The intent is to combine the carrier behavior of a peptide with the vasoactive/skin-conditioning effects associated with niacin esters. Niacin esters are well known in topical cosmetics; they can cause transient warmth or flushing in sensitive individuals at higher percentages but are well tolerated at typical use levels. There is no specific CIR or SCCS review for this conjugate. Independent peer-reviewed efficacy data is essentially absent; claims rely on supplier in vitro work.
Function
Skin benefits
- Skin conditioning
- Niacin-mediated microcirculation effects
- Low irritation at typical levels
Known concerns
- Possible transient flushing in sensitive users
- Limited independent data
- No regulatory dossier
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.