Antioxidant
DISODIUM PHLORETIN DISULFONATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A water-soluble sulfonated derivative of phloretin, the apple polyphenol. More stable than the parent, activity partially retained.
Disodium phloretin disulfonate is a synthetic, water-soluble derivative of phloretin (a dihydrochalcone found in apple bark and leaves). Sulfonation at two positions produces a disodium salt that is much more water-soluble and formulation-stable than free phloretin. Phloretin is studied as a skin antioxidant and is paired with vitamin C in some dermocosmetic brands. The sulfonated derivative has reduced cell uptake and likely reduced intrinsic antioxidant potency, but is easier to incorporate into aqueous formulas. No CIR/SCCS opinion; data on this specific derivative is mostly supplier-generated.
Function
Skin benefits
- Water-soluble disulfonate of the apple polyphenol phloretin
- Antioxidant activity
- More formulation-stable than free phloretin
Known concerns
- Sulfonation reduces natural activity — efficacy debated
- Limited independent cosmetic studies
- No CIR/SCCS opinion on this derivative
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.