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DODOXYNOL-5

CAS 9014-92-0 / 26401-47-8
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dodoxynol-5 is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Dodoxynol-5 is an alkylphenyl polyethoxylate (APEO) based on dodecylphenyl, structurally related to the Nonoxynol and Octoxynol series. APEOs are subject to EU restrictions under REACH due to concerns about their degradation products (alkylphenols) which are persistent, bioaccumulative, and endocrine-disrupting. While Dodoxynol-5 is not individually listed in EU Annex II or III, the entire APEO class faces increasing regulatory pressure in cosmetic applications. Dodoxynol-5 has moderate irritation potential and the same 1,4-dioxane contamination risk as other ethoxylated surfactants. Many EU formulators have moved away from APEOs in favor of fatty alcohol ethoxylates.

Skin benefits

  • Effective emulsifier across wide pH range
  • Good solublizing properties
  • Stable in hard water

Known concerns

  • Endocrine-disrupting alkylphenol metabolites
  • EU REACH restrictions on APEOs in cosmetic formulations
  • 1,4-dioxane contamination risk
  • Environmental toxicity and bioaccumulation potential
  • Skin and eye irritation at use concentrations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.