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estrone

CAS 53-16-7
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Estrone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Estrone is a natural estrogenic hormone (E1) with documented endocrine activity. In the EU, estrogenic hormones and their derivatives are explicitly listed in CosIng Annex II as prohibited substances for cosmetic use. This reflects the well-established risk of hormonal disruption from topical application of these compounds. The absence of GHS hazard statements in this specific entry reflects reporting variation, not safety — estrone is a known endocrine disruptor with established reproductive and developmental toxicity pathways.

Known concerns

  • Endocrine-disrupting estrogenic activity
  • CMR substance — Annex II entry specifically prohibits cosmetic use
  • Established reproductive and developmental toxicity risk
  • No safe cosmetic use established at any concentration

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.