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HC YELLOW NO. 6

CAS 104333-00-8
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hc Yellow No. 6 is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

HC Yellow No. 6 is listed in EU Annex II/1324 of Cosmetics Regulation 1223/2009, indicating a restriction or prohibition status. Like other HC dyes, its nitroaniline/sulphanilic acid derivative structure is associated with allergic contact dermatitis in both consumers and hairdressers. Patch test data from dermatological studies show cross-reactivity with other azo and nitro dyes. The restriction reflects accumulated safety data indicating sensitisation risk outweighing cosmetic benefit in many jurisdictions, though the compound remains in use under tightly controlled conditions in some markets.

Known concerns

  • EU Annex II/1324 restricted
  • Skin sensitisation potential
  • Cross-reactivity with other azo/nitro dyes
  • Documented contact dermatitis cases

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.