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Signal peptide

HEXAPEPTIDE-20

CAS -
76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Hexapeptide-20 is a synthetic signal peptide marketed for relaxing expression lines. It has a favourable safety profile though independent efficacy data are limited.

Function

SKIN CONDITIONING

Skin benefits

  • Synthetic signal peptide marketed for muscle relaxing anti-wrinkle effects
  • Generally non-irritating at typical use levels of 1 to 5%
  • Compatible with a wide range of anti-ageing formulations
  • Stable in aqueous serums at neutral pH

Known concerns

  • Clinical evidence for wrinkle reduction is mostly supplier-funded
  • Peptides can be unstable in formulations with high pH or certain actives
  • Limited independent safety review for repeated long-term use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.