Skip to content

Signal peptide

PENTAPEPTIDE-46

75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Pentapeptide-46 is a five-amino-acid signal peptide used in anti-ageing formulas to support collagen and firmness. Like other pentapeptides, it is generally well tolerated but has limited public safety data.

Function

SKIN PROTECTING

Skin benefits

  • Synthetic pentapeptide used as a skin conditioning signal peptide
  • Pentapeptide class supports collagen and matrix proteins
  • Effective at low parts-per-million levels
  • Generally non-irritating at typical use

Known concerns

  • Limited published safety and efficacy data on this specific peptide
  • No CIR or SCCS opinion specifically for Pentapeptide-46
  • Stability and delivery in formulations can be challenging

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related signal peptides

75
HEXAPEPTIDE-70
Signal peptide
 74
DECAPEPTIDE-73
Signal peptide
 76
HEXAPEPTIDE-20
Signal peptide
 74
OLIGOPEPTIDE-220
Signal peptide
 72
PENTAPEPTIDE-82
Signal peptide
 78
TETRAPEPTIDE-138
Signal peptide
 78
TETRAPEPTIDE-57
Signal peptide
 70
PENTAPEPTIDE-47
Signal peptide

Check your shelf

Find PENTAPEPTIDE-46 in your products.

Scan any cosmetic product with LuxSense to see if it contains PENTAPEPTIDE-46 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.