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Skin Conditioning

PENTAPEPTIDE-46

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic 5-amino-acid peptide for skin conditioning. Plausibly safe at trace levels; independent data is limited.

Pentapeptide-46 is a synthetic pentapeptide (5 amino acids) supplied as a cosmetic skin-conditioning active at parts-per-million levels. Numbered INCI pentapeptides are typically marketed by specialty ingredient houses for signaling-type benefits (firmness, smoothness, visible-aging support). There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides have negligible intact skin penetration and very low irritation potential at use levels. Independent efficacy and long-term safety data are thin; practical risk is dominated by carriers, preservatives, and counterions in the finished formula.

Function

SKIN PROTECTING

Skin benefits

  • Skin conditioning
  • Marketed firming/smoothing support
  • Low irritation potential

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.