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Signal peptide

TETRAPEPTIDE-138

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Tetrapeptide-138 is a four-amino-acid signal peptide used at trace levels in skincare to support firmness and a smoother appearance. It is generally well tolerated, though independent clinical evidence remains limited.

Function

HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Short signalling peptide designed for skin-conditioning effects
  • Peptides in this class often target firmness or wrinkle reduction
  • Used at very low concentrations in serums and creams

Known concerns

  • Limited publicly available clinical data on this specific peptide number
  • Marketing claims often outpace published evidence
  • May be costly relative to demonstrated benefit

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Check your shelf

Find TETRAPEPTIDE-138 in your products.

Scan any cosmetic product with LuxSense to see if it contains TETRAPEPTIDE-138 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.