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Fragrance

HEXYL HEXANOATE

CAS 6378-65-0
84

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A simple fatty ester (hexanol + hexanoic acid) with apple-pineapple fruity notes. FEMA GRAS flavor listing and a clean cosmetic profile.

Hexyl hexanoate (CAS 6378-65-0) is the ester of n-hexanol and n-hexanoic acid, naturally present in apples and pineapples and widely used as both flavor and fragrance. It carries FEMA GRAS flavor approval and is inventoried for fragrance use under RIFM. Standard fatty esters are rapidly cleaved by endogenous esterases to the parent alcohol and acid, both of which are well-tolerated. GHS hazards are typically limited to mild eye irritation at neat levels. Not an EU Annex III declared fragrance allergen. Good tier scoring reflects both the safety record and the abundance of supporting data.

Function

PERFUMING

Skin benefits

  • Fruity fragrance/flavor note
  • Stable ester
  • Low irritation

Known concerns

  • Fragrance allergen load consideration

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.