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HYDROXYETHYL-2,6-DINITRO-P-ANISIDINE

CAS 122252-11-3
32

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A dinitro-substituted anisidine hair dye precursor restricted in the EU Annex III, with significant safety concerns around nitro compound toxicity.

Hydroxyethyl-2,6-dinitro-p-anisidine is a dinitro-substituted aromatic amine hair dye intermediate restricted under EU Annex III/II/1320. Having two nitro groups on the aromatic ring significantly raises toxicological concern—the SCCS has flagged multiple dinitro aromatic compounds for their potential to generate reactive oxygen species and for arylamine exposures during hair processing. The hydroxyethyl substitution increases water solubility and potentially modifies dermal penetration compared to simpler dinitroanilines.

Skin benefits

  • Provides deep violet to blue tones in hair dye formulations
  • Acts as a coupler in combination with specific primary intermediates

Known concerns

  • EU Annex III restricted (II/1320)
  • Dual nitro group substitution raises oxidative stress concern
  • Potential for carcinogenic arylamine release under reducing conditions
  • The SCCS has expressed concern about dinitro-substituted hair dye safety profiles

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.